작성일 : 18-10-27
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Purity 99%, ROCK Inhibitor Y-27632
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글쓴이 :
운영자
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ROCK Inhibitor (Y-27632)
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide Dihydrochloride
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki=
140 nM for p160ROCK (ROCK-I). Also inhibitsROCK-II with almost equal potency. Inhibition is achieved by
competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCεthan
p160ROCK. Does not affect the activity of p21-activated protein kinase(PAK) even at high concentrations
(~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation
and smooth muscle contractions (IC50 = 700 nM for phenylephrine-inducedcontractions in aortic strips).
Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hEScells without
affecting their pluripotency.
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(1E,4S,4aR,5R,6aS,7S,9aR)-5-(Acetyloxy)-1-[[[3-(dimethylamino)propyl]
methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-
(methoxymethyl)-4a,6a-dimethylcyclopenta[5,6]na-phtho[1,2-c]pyran-2,10(1H,4H)
-dione
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Protect from light. Packaged under inert gas
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1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681;
2. Chitaley, K. et al. Nat. Med. 2001, 7, 119;
3. Davies, S. P. et al. Biochem. J. 2000, 351, 95;
4. Narumiya, S. et al. Methods Enzymol. 2000, 325, 273;
5. Hirose, M. et al. J. Cell Biol. 1998, 141, 1625;
6. Maekawa, M. et al. Science 1999, 285, 895;
7. Uehata, M. et al. Nature 1997, 389, 990.
Ordering information
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Catalog No.
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Product Name
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Size
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CD0141
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ROCK Inhibitor (Y-27632)
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1mg, 5mg, 10mg, 25mg, 50mg ,100mg, 250mg & 1g
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▣ 관련 페이지 ; Chemdea
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