작성일 : 18-06-25
Cites Cleanascite™ To Deplete Extracellular Vesicles
 글쓴이 : 운영자
 

 

클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요

 

 

News Release

 

Journal Article Cites Cleanascite™ To Deplete Extracellular Vesicles

MONMOUTH JUNCTION, NJ, June 14, 2018 -- Biotech Support Group reports on a recent journal article

describing the simplicity and efficiency of their lipid binding sample preparation technology for depleting the

influence of extracellular vesicles – also known as EVs or exosomes, on cell-cell communication.

 

The citation is:

Nguyen, Doan C., et al. "Extracellular vesicles from bone marrow-derived mesenchymal stromal cells support ex vivo survival of human antibody secreting cells." Journal of extracellular vesicles 7.1 (2018): 1463778.

 

Bone marrow-derived mesenchymal stromal cells (MSC) have been shown to support human antibody

secreting cells (ASC) survival ex vivo. Extracellular vesicles from bone marrow-derived mesenchymal

stromal have novel mechanisms of cell-cell communication over short and long distances, but whether the

crosstalk between these cell interactions can occur via extracellular vesicles is not known.

Thus, the study investigated the role of extracellular vesicles (EVs) in antibody secreting cell survival and

IgG secretion. The article states “To understand whether disrupting the lipid plasma membrane that upsets

the integrity of the EVs would compromise the survival activity of either the non-irradiated or irradiated

secretomes, …We then cultured ASC with conventional media (vehicle), secretome from irradiatedMSC, or

secretome from irradiated MSC that had been pretreated with the lipid-disrupting agent Cleanascite [28],

which is known not to alter protein functionality [29]. Cleanascite-treatment of the secretome dramatically

reduced ASC functional survival, … Similar reductions were also noted with the secretome of non-irradiated

MSC when treated with Cleanascite … These results demonstrate that lipid-membrane bodies, such as EVs,

could mediate important ASC survival factors within the MSC secretome.”

 

“This reference shows that Cleanascite™ can simply and efficiently bind the lipid membrane complex

necessary for studying extracellular vesicle communication between cells. This demonstrates the advantage

of using an aqueous suspension product with no solvents, to deplete lipid associated factors that may

influence cell response investigations. The exosome depletion is quite impressive” states Swapan

Roy,Ph.D., President and Founder of Biotech Support Group.

 

For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification,

at

https://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm

  

 

▣ 관련 페이지 ; Biotech Support Group