Patent Application Describes HemoVoid™ To Uncover Proteomic Changes from

Autologous Blood-doping

MONMOUTH JUNCTION, NJ, January 15, 2021 --Biotech Support Group reports on a patent

application describing the simplicityand efficiency of their hemoglobin depletion technology for

human stored redblood cells. The citation is:

Christer, M. A. L. M., et al. "Methods for the detection of autologous blood-doping." U.S. Patent

Application No. 16/976,936.

The patent application relates to the identification of peptides, andthe corresponding proteins,

that can be used in methods for the detection ofautologous blood doping. More specifically, the

invention relates to methodscomprising tryptic digestion of samples of isolated red blood cell

(RBC),specifically isolated RBC cytosol, followed by peptide mapping using liquidchromatography

tandem-mass spectroscopy (LC-MS/MS). Theinvention’s description states “Hemoglobin depletion was

performed usingHemoVoid resin, buffers and filter tubes as described by the manufacturer(Biotech Support

Group) using a standard bench-top centrifuge.”. Uponthe preferable depletion of hemoglobin, the

methods enable detection ofincreased levels of certain peptides in samples from subjects that

have beensubjected to autologous blood doping, compared to samples from non-dopedcontrol

subjects.

“There is great interest in understanding theproteomic changes in red cells upon storage or in

disease states. Being able toquantify these changes using LC-MS/MS is very important to help

testing forautologous blood-doping and possibly other conditions. As this patentapplication

describes, proteomic analysis is a very productive way to uncoverand measure these important

changes. I am pleased that our Hemo-Void™ productis proving to be quite useful for these

purposes” states Swapan Roy, Ph.D.,President and Founder of Biotech Support Group.

For more information on HemoVoid™, visit:

https://www.biotechsupportgroup.com/HemoVoid-Hemoglobin-Depletion-From-Erythrocytes-p/hvk.htm

For more information on all of our Hemoglobin Removal Products, visit:

https://www.biotechsupportgroup.com/Hemoglobin-Removal-s/312.htm