Macrophage의 제거에 유용한 Clodronate Liposomes을 위한 Fluorescent Control Liposomes 입니다.

Clodronic acid를 내포한 liposome으로서, 생체에 투여하면 splenic macrophage에 작용하여 macrophage를 제거할 수 있습니다. Liposome을 구성하는 lipid electric charge가 다른 Clophosome(Neutral) 또는 Clophosome A(Anionic)의 두 가지 제품이 있습니다.

특 징 ;

Clophosome

Clophosome-A

Example of results ; 

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.v. injection of liposomes (results used with permission)

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.p. injection of liposomes (results used with permission)

(Note: the above results are illustrations only, your results may vary depending on individual applications, types of animals and administration regimens and many other factors)

IMPORTANT NOTES FOR USING CLOPHOSOMES

CLEAN with alcohol and DO NOT reuse the needles

Animals become sensitive to infection when macrophages are depleted and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean.  Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosomes.

A good practice is to include a few extra animals in the study, as occasional animal death is common for these types of work. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.

Liposome에 관한 FAQ

Ordering informations

* Size ; 2 ml & 10 ml

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