FormuMax Scientific
작성일 : 17-07-24
[FormuMax Scientific] Lyophilized Clophosome® Clodronate Liposomes


Lyophilized Clophosome® Clodronate Liposomes, 12 months guaranteed

Superior Macrophage Depletion Efficiency



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Clodronic acid를 내포한 liposome으로서, 생체에 투여하면 splenic macrophage에 작용하여 macrophage를

제거할 수 있습니다. Liposome을 구성하는 lipid electric charge가 다른 Clophosome(Neutral) 또는 Clophosome

A(Anionic)의 두 가지 제품이 있습니다.



특 징 ;

  • 생체 내의 macrophage를 고효율로 제거할 수 있습니다.

  • Clodronic acid가 phosphatidylcholine과 cholesterol로 구성된 multilayer liposome에 내포되어 있어 활동, 물리적, 화학적 안정성이 우수합니다.

  • 매우 높은 clodronic acid/지질 비율을 가집니다.

  • 유리 clodronic acid은 제거되고, liposome에의 clodronic acid의 enclosure rate는 90% 이상입니다.

  • 정맥 주사, 복강내 투여, 피하 투여, 비강내 투여, 기관내 투여 등 다양한 방법으로 생체 내에 주입할 수 있습니다.

  • 4 종류의 liposome을 포함한 세트(# F70101C-NA) 외에 control liposome을 포함한 세트도 있습니다.



  • 중성 liposome에 clodronic acid가 내포되어 있습니다.

  • 생체에 정맥 주사로 1회 투여하는 것 만으로도, splenic macrophage를 약 80 ~ 90% 제거할 수 있습니다.

  • 점성이 없고 취급이 용이합니다.



Clophosome® (Neutral)


Clophosome®-A (Anionic)

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Clophosome® (neutral) and Clophosome®- A (anionic) have become increasingly popular for in vivo

macrophage depletion. However their limitation has been their short shelf-life. The good news is now we are

offering lyophilized Clophosome®with a guaranteed 12 month shelf-life. By simple reconstitution in water

one gets simply the best clodronate liposome products onthe market(see more details below). Once

reconstituted it is used the same way as thestandard liquid Clophosome® (F70101C-N or F70101C-A).

Excellent macrophage depletion efficiency of > 80% is achievable with one dose of the neutral Clophosome®

and even higher depletion ( > 90%) with the anionic Clophosome®- A. Long-term macrophage depletion for

weeks is also achievable with multiple dosing. Since the launch five years ago, Clophosome®has become

the number one choice for in vivo macrophage depletionamong immunologists, oncologists and other life

science researchers all overthe world.


* Control liposomes for this product: F70101-N or F70101-A




Brand Name:



clodronate disodium. CAS: 22560-50-5

Clodronate disodium (liposome encapsulated):

7 mg/mL

Lipid composition:

phosphatidylcholine & cholesterol or


phosphatidylcholine, phosphotidyglycerol & cholesterol


Lyophilized cake/powder from PBS (10% sucrose, 20mM


Na phosphate), pH 7.0-7.5


2-8°C recommended


12 months guaranteed for unopened vials


Reconstitution:We recommend using sterile water for reconstitution. Add 4.5 ml sterile pure water into the vial

at room temperature and mix by invert the vial several times. Let it stand on bench for  2-3 min and vortex 2-

3 times (30-60 sec each vortex) at medium speed. The liposomes can be used in 10 min after reconstitution.

Make sure there is no lumps or anynoticeable particles. Vortex more if this occurs until homogeneous.


Reconstituted product can be stored in refrigerator for up to 3 months (not guaranteed) when handled cleanly.

For best shelf-life for the reconstituted liposomes inject water through the rubber stopper using a sterile

syringe needle.  



Example of results ; 


Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen

24 hr after i.v. injection of liposomes (results used with permission)



Brochure (PDF)



Ordering informations


Catalog No.

Product Name



Lyophilized Clophosome® Clodronate Liposomes - Neutral

5 ml


Lyophilized Clophosome® Clodronate Liposomes - Anionic

5 ml



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