뇌 질환 연구용 EGFRvIII 과발현 세포주

 

 

U87MG vIII 4.12

 

The U87MG vIII 4.12 clone cell line is a permanent line established from cell line derived from malignant

glioma, classified as glioblastoma. U87MG vIII (4.12) cell line stably expresses high level of EGF mutant

receptor vIII and G418-resistant genes introduced by plasmid stable transfection.

   

Form:

 

Cryopreserved

Organism:

 

Homo sapiens, human

Tissue:

 

Brain

Disease:

 

Glioblastoma, astrocytoma

Morphology:

 

Epithelial

Growth Properties:

 

Adherent

Product Format:

 

frozen 1 mL, 1x106 cells/vial

  

 

T96/EGFRvIII

 

The T96 cell line is established from glioblastoma multiforme. The T96/EGFRvIII with additional point mutation

C311Y cell line stably expresses mutated EGFRvIII and neomicin-resistant genes. Both mutated EGFRvIII and

neomicin-resistant genes are under CMV promoter control, allowing high levels of protein expression.

   

Form:

 

Cryopreserved

Organism:

 

Homo sapiens, human

Tissue:

 

Brain

Disease:

 

Glioblastoma

Growth Properties:

 

Adherent

Product Format:

 

frozen 1 mL, 1x106 cells/vial

  

 

DKMG/EGFR vIII

 

Application of the DKMG/EGFRvIII cell line opens new perspectives in EGFRvIII research. EGFRvIII

expression was reinduced in cells, which expressed EGFRvIII in vivo, but due to unknown reasons did not in

vitro. DKMG cells show mutation at DNA level, which is responsible for the expression of EGFRvIII mRNA and

protein, however, in most of these cells the expression of mutatant EGFR gene copies is silenced (these

cells show the amplification of this gene). The performed biotechnological modification results in the EGFRvIII

expression in all cells of the DKMG cell line.

    

Form:

 

Cryopreserved

Organism:

 

Homo sapiens, human

Tissue:

 

Brain

Disease:

 

Glioblastoma

Growth Properties:

 

Adherent

Product Format:

 

frozen 1 mL, 1x106 cells/vial

  

 

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