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작성일 : 19-11-19
[Immudex ApS] Melanoma Dextramer Collection 1

 

Dextramer Packages, Melanoma Dextramer Collection 1

 

Dextramer packages and collections are carefully selected sets of Dextramer reagents for monitoring

antigen-specific T-cell responses in different diseases.

 

Melanoma Dextramer Collection 1

 

Melanoma is a malignant neoplasm of melanocytes arising de novo or from a pre-existing benign nevus.

 

Tumor-reactive T cells specific for a range of melanoma-associated antigens have been isolated from

melanoma patients. Important melanoma-antigens include melanocyte lineage proteins like Tyrosinase,

gp100, MART-1 and Cancer-Testis antigens like the MAGE proteins and NY-ESO-1. These are all potentially

suitable targets for tumor vaccines because of their high immunogenicity in vivo and their restricted

distribution in normal tissue.

Melanoma-specific immunity can be determined by detection of CD8+  melanoma antigen-specific T cells in

peripheral blood and in the tumor of melanoma patients, using melanoma-specific Dextramers.

 

Features

• Accurate quantification of melanoma-specific T cells

• Specific, sensitive,  reproducible

• Applicable on blood, HPBMC, tissue sections

 

Benefits:

• Accurate quantification of melanoma-specific T cells

• Specific, sensitive,  reproducible

• Applicable on blood, HPBMC, tissue sections

 

Applications

• Monitoring of pre-existing immunity

• Monitoring of induced immunity

* The Melanoma Dextramer Collection 1 is useful for detection, enumeration and isolation of cancer-specific

  CD8+ T cells in a variety of application e.g. during cancer vaccine and immunotherapeutic development:

  Read more (PDF)

 

The Melanoma Dextramer Collection 1 consists of Dextramer reagents displaying epitopes from 6 different

melanoma-associated antigens MART-1, NY-ESO-1, MAGE-A3, Tyrosinase, gp100 and MAGE-A1. The

collection also includes a negative control Dextramer.

Each Dextramer-specificity in the collection is provided as a PE- and a APC conjugate, allowing double

staining of each cell sample to better resolve positive from negative cell populations.

  

 Kit components

    

 Catalog No.

 Dextramer

 Antigen

Size

 WB2162-PE

 HLA-A*0201 / ELAGIGILTV-PE

 MART-1

25 tests

 WB2162-APC

 HLA-A*0201 / ELAGIGILTV-APC

 MART-1

25 tests

 WB3247-PE

 HLA-A*0201 / SLLMWITQV-PE

 NY-ESO-1

25 tests

 WB3247-APC

 HLA-A*0201 / SLLMWITQV-APC

 NY-ESO-1

25 tests

 WB3497-PE

 HLA-A*0201 / KVAELVHFL-PE

 MAGE-A3

25 tests

 WB3497-APC

 HLA-A*0201 / KVAELVHFL-APC

 MAGE-A3

25 tests

 WB3245-PE

 HLA-A*0201 / YMDGTMSQV-PE

 Tyrosinase

25 tests

 WB3245-APC

 HLA-A*0201 / YMDGTMSQV-APC

 Tyrosinase

25 tests

 WB2158-PE

 HLA-A*0201 / IMDQVPFSV-PE

 gp100

25 tests

 WB2158-APC

 HLA-A*0201 / IMDQVPFSV-APC

 gp100

25 tests

 WB3474-PE

 HLA-A*0201 / KVLEYVIKV-PE

 MAGE-A1

25 tests

 WB3474-APC

 HLA-A*0201 / KVLEYVIKV-APC

 MAGE-A1

25 tests

 WB2666-PE

 HLA-A*0201 / Negative Control-PE

 -

25 tests

 WB2666-APC

 HLA-A*0201 / Negative Control-APC

 -

25 tests

 

Related products

The melanoma-specific Dextramer reagents in the Melanoma Dextramer Collection 1 are also available as

single reagents.

Additional melanoma-specific Dextramer reagents not provided in Melanoma Dextramer Collection 1 are

available. For further information search for melanoma Dextramer reagents in the product database.

 

 

Ordering information

    

Catalog No.

Product Name

Size

 RX01

Melanoma Dextramer® Collection 1

25 tests each

 

 

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