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작성일 : 19-11-19
[Immudex ApS] Cancer-Testis Antigen Dextramer Collection 1

 

Dextramer Packages, Cancer-Testis Antigen Dextramer Collection 1

Detecting cancer-specific immunity

 

Cancer-Testis antigens  (CTA) constitute a family of proteins that exhibit a remarkably restricted expression

in gametogenic tissue and are therefore not exposed to the systemic immune system. This means that no

immunological tolerance is established. CTA are over-expressed and cellular immune responses have been

reported in patients with a variety of tumors. CTA-specific immunity can be determined by detection of CD8+

CTA-specific T cells in peripheral blood and in tumor biopsies.  

 

Features

• Accurate quantification of Cancer-specific T cells

• Specific, sensitive, reproducible

• Applicable on blood, HPBMC, tissue sections

 

Applications

The Cancer-testis Antigens Dextramer Collection 1 is useful for detection and isolation of cancer-specific

CD8+ T cells in a variety of applications:

• Monitoring of pre-existing immunity

• Monitoring of induced immunity

• Testing of CTA-specific vaccines

• Profiling of CTA-specific T-cell responses

  Read more (PDF)

 

The Cancer-Testis Antigens Dextramer Collection 1 consists of Dextramers displaying epitopes from 3

different Cancer-Testis antigens; NY-ESO-1, MAGE-A3 and MAGE-A1. The collection also includes a

negative control Dextramer.

Each Dextramer specificity in the collection is provided as a PE- and APC conjugate, allowing  double

staining of each cell sample to better resolve positive from negative cell populations.

 

  Kit components

     

 Catalog No.

 Dextramer

 Antigen

Size

 WB3247-PE

 HLA-A*0201 / SLLMWITQV-PE

 NY-ESO-1

25 tests

 WB3247-APC

 HLA-A*0201 / SLLMWITQV-APC

 NY-ESO-1

25 tests

 WB3497-PE

 HLA-A*0201 / KVAELVHFL-PE

 MAGE-A3

25 tests

 WB3497-APC

 HLA-A*0201 / KVAELVHFL-APC

 MAGE-A3

25 tests

 WB3474-PE

 HLA-A*0201 / KVLEYVIKV-PE

 MAGE-A1

25 tests

 WB3474-APC

 HLA-A*0201 / KVLEYVIKV-APC

 MAGE-A1

25 tests

 WB2666-PE

 HLA-A*0201 / Negative Control-PE

 -

25 tests

 WB2666-APC

 HLA-A*0201 / Negative Control-APC

 -

25 tests

 

Related products

The CTA-specific Dextramer reagents in the Cancer-Testis Antigens Dextramer Collection 1 are also

available as single reagents.

Additional CTA-specific Dextramer reagents not provided in Cancer-Testis Antigen Dextramer Collection 1

are available. For further information search for CTA Dextramer reagents in the product database,

 

 

Ordering information

    

Catalog No.

Product Name

Size

 RX02

Cancer-Testis Antigen Dextramer® Collection

25 tests each

 

 

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