Dextramer Packages, CMV Dextramer Package
Detecting CMV-specific immunity
Cytomegalovirus (CMV) is a herpes virus that infects 60-90% of the adult population but remains latent in
healthy individuals because of the presence of CMV-specific T cells. In healthy individuals an equilibrium is
maintained where CMV-specific T cells control the persisting virus. When T cell function is impaired and
equilibrium is not maintained, CMV reactivation and clinical disease can develop. Quantification of CMV-
specific CD8+ T cells helps determine the CMV-specific immune status.
Features
• Accurate quantification of CMV-specific T cells
• Includes multiple alleles
• Specific, sensitive, reproducible
• Applicable on blood, HPBMC, tissue sections
Applications
Dextramer CMV Package is usefull for detection and isolation of CMV-specific CD8+ T cells in a variety of
applications:
• Monitoring immune status following transplantation
• Monitoring viral immunity in immune-compromised individuals
• Testing of CMV-specific vaccines
• Profiling of CMV-specific T cell responses
Read more (PDF)
Dextramer CMV Package comprises Dextramer reagents displaying immunodominant, well-characterized
epitopes derived from the CMV proteins pp50, pp65 and IE1, which can accurately detect and quantify CMV-
specific T cells in blood. The package also includes one negative control Dextramer.
Kit components
Catalog No.
|
Dextramer
|
Antigen
|
Size
|
WA2131
|
HLA-A*0101 / VTEHDTLLY
|
pp50
|
50 tests
|
WB2132
|
HLA-A*0201 / NLVPMVATV
|
pp65
|
2 x 50 tests
|
WC2197
|
HLA-A*0301 / KLGGALQAK
|
IE-1
|
50 tests
|
WF2133
|
HLA-A*2402 / QYDPVAALF
|
pp65
|
50 tests
|
WH2135
|
HLA-B*0702 / RPHERNGFTVL
|
pp65
|
50 tests
|
WH2136
|
HLA-B*0702 / TPRVTGGGAM
|
pp65
|
50 tests
|
WI2137
|
HLA-B*0801 / ELRRKMMYM
|
pp65
|
50 tests
|
WK2138
|
HLA-B*3501 / IPSINVHHY
|
pp65
|
50 tests
|
NI3233
|
General / Negative Control
|
-
|
2 x 50 tests
|
Related products
The CMV Dextramer reagents in the CMV Dextramer Package are also available as single reagents
Additional CMV-specific Dextramer reagents not provided in CMV Dextramer package are available. These
display other epitopes from the same antigens and epitopes restricted by other alleles. For further information
search for CMV Dextramer reagents in the product database.
|