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작성일 : 19-11-20
[Immudex ApS] CMV Dextramer Package

 

Dextramer Packages, CMV Dextramer Package

Detecting CMV-specific immunity

 

Cytomegalovirus (CMV) is a herpes virus that infects 60-90% of the adult population but remains latent in

healthy individuals because of the presence of CMV-specific T cells. In healthy individuals an equilibrium is

maintained where CMV-specific T cells control the persisting virus. When T cell function is impaired and

equilibrium is not maintained, CMV reactivation and clinical disease can develop. Quantification of CMV-

specific CD8+ T cells helps determine the CMV-specific immune status.

 

Features

• Accurate quantification of  CMV-specific T cells

• Includes multiple alleles

• Specific, sensitive, reproducible

• Applicable on blood, HPBMC, tissue sections

 

Applications

Dextramer CMV Package is usefull for detection and isolation of CMV-specific CD8+ T cells  in a variety of

applications:

• Monitoring immune status following transplantation

• Monitoring viral immunity in immune-compromised individuals

• Testing of CMV-specific vaccines

• Profiling of CMV-specific T cell responses

  Read more (PDF)

 

Dextramer CMV Package comprises Dextramer reagents displaying immunodominant, well-characterized

epitopes derived from the CMV proteins pp50, pp65 and IE1, which can accurately detect and quantify CMV-

specific T cells in blood. The package also includes one negative control Dextramer.

 

 Kit components

   

 Catalog No.

 Dextramer

  Antigen

Size

 WA2131

 HLA-A*0101 / VTEHDTLLY

  pp50

50 tests

 WB2132

 HLA-A*0201 / NLVPMVATV

  pp65

2 x 50 tests

 WC2197

 HLA-A*0301 / KLGGALQAK

  IE-1

50 tests

 WF2133

 HLA-A*2402 / QYDPVAALF

  pp65

50 tests

 WH2135

 HLA-B*0702 / RPHERNGFTVL

  pp65

50 tests

 WH2136

 HLA-B*0702 / TPRVTGGGAM

  pp65

50 tests

 WI2137

 HLA-B*0801 / ELRRKMMYM

  pp65

50 tests

 WK2138

 HLA-B*3501 / IPSINVHHY

  pp65

50 tests

 NI3233

 General / Negative Control

  -

2 x 50 tests

 

Related products

The CMV Dextramer reagents in the CMV Dextramer Package are also available as single reagents

Additional CMV-specific Dextramer reagents not provided in CMV Dextramer package are available. These

display other epitopes from the same antigens and epitopes restricted by other alleles. For further information

search for CMV Dextramer reagents in the product database.

 

 

Ordering information

    

Catalog No.

Product Name

Size

CMV-PACK-PE, -APC, -FITC

CMV Dextramer Package

-

 

 

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