FormuMax Scientific
작성일 : 20-02-10
[FormuMax Scientific] Alendrosome™ - A- Alendronate Liposomes (Anionic)


Alendrosome™ - A- Alendronate Liposomes (Anionic)


                    클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요


Alendronate molecules are encapsulated in liposomes for superior activity, physical and chemical stability,

and convenience of use. The liposomal encapsulation efficiency of alendronate is no less than 90%. The

product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous,

intranasal, intratracheal and etc. It is sterile filtered for long term shelf-life. There are some but limited studies

on Alendronate liposomes and this product is made available for research studies only.


We, FormuMax are looking for researchers to test our Alendrosome™ products, please contact us if you are




• Active: alendronate sodium (CAS 121268-17-5), 5.0 mg/mL

       클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요

• Volume: 2.0 mL

• Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol

• Internal/External solution: phosphate buffered saline (20mM sodium phosphate, 09wt% NaCl), pH 7.0 - 7.5

• Usage: warm to room temperature and mix well before use.

• Dosage: this is a new product and no recommended dose is available at this point. Refer the following

  literature for additional information



1. Benjamin J. Burwitz et al. Technical Advance: Liposomal alendronate depletes monocytes and

   macrophages in the nonhuman primate model of human disease. J Leukoc Biol. 2014 Sep; 96(3): 491–501.

   PMC4632165 (Link)

2. Renate Frei, Comparison of cytotoxic properties of free and liposomal bisphosphonates in vitro (Diploma

   Thesis) (Link)

3. Mönkkönen J, van Rooijen N, Ylitalo P., Effects of clodronate and pamidronate on splenic and hepatic

   phagocytic cells of mice. Pharmacol Toxicol. 1991 Apr;68(4):284-6. (Link)

4. Makkonen N, Hirvonen MR, Teräväinen T, Savolainen K, Mönkkönen J., Different effects of three

   bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. J Pharmacol Exp

   Ther. 1996 May;277(2):1097-102 (link)

5. van Rooijen N, Kors N. Effects of intracellular diphosphonates on cells of the mononuclear phagocyte

   system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations

   in the spleen. Calcif Tissue Int. 1989 Sep;45(3):153-6. (Link)

6. Epstein H. et al., Preparation of alendronate liposomes for enhanced stability and bioactivity: in vitro and in

   vivo characterization.  AAPS J. 2008 Dec;10(4):505-15. Epub 2008 Oct 21. (Link)



Ordering informations


Catalog No.

Product Name



Alenphosome™ -A- Alendronate Liposomes (Anionic)

2.0 ml


Control liposomes for Alenphosome™ - (Anionic)

2.0 ml



▣ 관련 페이지 ; FormuMax Scientific