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Alendrosome™ - A- Alendronate Liposomes (Anionic)
Alendronate molecules are encapsulated in liposomes for superior activity, physical and chemical stability,
and convenience of use. The liposomal encapsulation efficiency of alendronate is no less than 90%. The
product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous,
intranasal, intratracheal and etc. It is sterile filtered for long term shelf-life. There are some but limited studies
on Alendronate liposomes and this product is made available for research studies only.
We, FormuMax are looking for researchers to test our Alendrosome™ products, please contact us if you are
interested.
Specifications
• Active: alendronate sodium (CAS 121268-17-5), 5.0 mg/mL
• Volume: 2.0 mL
• Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol
• Internal/External solution: phosphate buffered saline (20mM sodium phosphate, 09wt% NaCl), pH 7.0 - 7.5
• Usage: warm to room temperature and mix well before use.
• Dosage: this is a new product and no recommended dose is available at this point. Refer the following
literature for additional information
References
1. Benjamin J. Burwitz et al. Technical Advance: Liposomal alendronate depletes monocytes and
macrophages in the nonhuman primate model of human disease. J Leukoc Biol. 2014 Sep; 96(3): 491–501.
PMC4632165 (Link)
2. Renate Frei, Comparison of cytotoxic properties of free and liposomal bisphosphonates in vitro (Diploma
Thesis) (Link)
3. Mönkkönen J, van Rooijen N, Ylitalo P., Effects of clodronate and pamidronate on splenic and hepatic
phagocytic cells of mice. Pharmacol Toxicol. 1991 Apr;68(4):284-6. (Link)
4. Makkonen N, Hirvonen MR, Teräväinen T, Savolainen K, Mönkkönen J., Different effects of three
bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. J Pharmacol Exp
Ther. 1996 May;277(2):1097-102 (link)
5. van Rooijen N, Kors N. Effects of intracellular diphosphonates on cells of the mononuclear phagocyte
system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations
in the spleen. Calcif Tissue Int. 1989 Sep;45(3):153-6. (Link)
6. Epstein H. et al., Preparation of alendronate liposomes for enhanced stability and bioactivity: in vitro and in
vivo characterization. AAPS J. 2008 Dec;10(4):505-15. Epub 2008 Oct 21. (Link)
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작성일 : 20-02-10
