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작성일 : 22-04-21
[Iris Biotech] Permanent Linkers, Hydrophobic Spacer Molecules

 

Permanent Linkers, Hydrophobic Spacer Molecules

 

This class of linkers is considered non-cleavable, meaning linker cleavage and payload release do not

depend on the differential properties between plasma and cytoplasmic compartments. Instead, the release of

the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis

and delivery to lysosomal compartments, where the antibody is degraded to the level of amino acids through

intracellular proteolytic degradation. This process releases a drug derivative, formed by the cytotoxic drug,

the linker, and the amino acid residue to which the linker was covalently attached.

The following section displays examples of hetero-bifunctional PEG-based spacer molecules. As payloads

are quite often rather hydrophobic, PEG fragments help to solubilize the linker-payload conjugate, which is

essential to perform successful conjugation onto the antibody. It further helps to increase the solubility in

physiological media and to improve the pharmacokinetic properties of the whole ADC construct.

 

10-Undecynoyl-OSu

Chemical name:

 

10-Undecynoic acid N-hydroxysuccinimide ester

Cas-no.:

 

1006592-57-9

Formula:

 

C15H21NO4

Molecular weight:

 

279.34 g/mol

 

 

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Alkyne-myristic acid

Chemical name:

 

13-Tetradecynoic acid

Cas-no.:

 

82909-47-5

Formula:

 

C14H24O2

Molecular weight:

 

224.34 g/mol

 

 

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Alkyne-palmitic acid

Chemical name:

 

15-Hexadecynoic acid

Cas-no.:

 

99208-90-9

Formula:

 

C16H28O2

Molecular weight:

 

252.39 g/mol

 

 

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Alkyne-stearic acid

Chemical name:

 

17-Octadecynoic acid

Cas-no.:

 

34450-18-5

Formula:

 

C18H32O2

Molecular weight:

 

280.45 g/mol

 

 

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11-azido-undecanoyl-OSu

Chemical name:

 

11-azidoundecanoic acid N-hydroxysuccinimide ester -N

Cas-no.:

 

850080-13-6

Formula:

 

C15H24N4O4

Molecular weight:

 

324.38 g/mol

 

 

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Ordering informations

    

Catalog No.

Product Name

Size

RL-3460

10-Undecynoyl-OSu

250, 500mg, 1 & 5g

RL-2055

Alkyne-myristic acid

100, 500mg & 1g

RL-2060

Alkyne-palmitic acid

100, 500mg & 1g

RL-2065

Alkyne-stearic acid

500mg & 1g

RL-3170

11-azido-undecanoyl-OSu

250, 500mg, 1 & 5g

 

 

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