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작성일 : 22-04-25
[BroadPharm] Polymer PEG, Active ester

 

Polymer PEG (Polydisperse PEG)

 

Polymer PEG is a Polyethylene glycol (PEG) polymer with an averaged molecular weight, such as 2K, 5K,

10K, 20K with PDI ranging from 1.01-1.10. Polymer PEG is also known as polydisperse PEG, or Poly-PEG.

There are different shapes of Polymer PEG, such as linear, Y-shaped, branched, or star shaped with

different PEG chain lengths as shown in Figure 1. PEG chain can be attached with different functional groups

for chemistry modification and industrial application.

 

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Figure 1. Examples of Polymer PEG that are commercially available. Typical functional groups include

Acrylate, alkyne, Amine, Azide, DBCO, TCO, Aldehyde, Acid, NHS ester, Hydrazide, Maleimide, Silane,

Biotin, Tos, or Thiol.

 

Polymer PEG have become especially attractive tools in various pharmaceutical, biological and chemical

industry application due to its aqueous solubility, high flexibility and non-immunogenicity

  

 

Polymer PEG, Active ester

 

NHS ester-activated PEGylation polymer can react with primary amines at pH 7.2 to 9 to yield a stable

(covalent) amide bond. The reaction releases N-hydroxysuccinimide (NHS). Nucleophilic reaction between

amine and active ester is most commonly performed in phosphate, carbonate-bicarbonate, HEPES or borate

buffers at pH 7.2 to 8.5 for 0.5 to 4 h at room temperature or 4°C.

 

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DSPE-PEG-NHS

Catalog No.

Product Name

Size

Feature

Structure

BP-26254

DSPE-PEG-NHS, MW 600

100, 250 & 500mg

DSPE-PEG-NHS, MW 600 is a phospholipid PEG which can react with protein/peptide or other amine

molecule. The polymer forms lipid bilayer in an aquoeus solution and can be used to prepare liposomes for

drug delivery application, such as mRNA vaccine or cancer immunotherapy.

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BP-26220

DSPE-PEG-NHS, MW 1,000

100, 250 & 500mg

DSPE-PEG-NHS, MW 1,000 is an amine reactive phospholipid. The reaction between NHS ester and amine

forms a stable amide linkage. The polymer is amphiphilic which enables formation of micelles or lipid

bilayer in aqueous solution.

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BP-26221

DSPE-PEG-NHS, MW 2,000

100, 250 & 500mg

DSPE-PEG-NHS, MW 2,000 is a phospholipid PEG polymer which can be used to encapsulate

drugs/therapeutics agents in targeted drug delivery system, such as liposome based mRNA vaccine. The

NHS-ester is reactive with amine at pH 6.5 to 7.5 to form a stable amide bond.

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BP-26222

DSPE-PEG-NHS, MW 3,400

100, 250 & 500mg

DSPE-PEG-NHS, MW 3,400 is an amine reactive phospholipid which can be used to prepare liposome or

lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.

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BP-26223

DSPE-PEG-NHS, MW 5,000

100, 250 & 500mg

DSPE-PEG-NHS, MW 5,000 is a polydisperse PEG attached with phospholipid. The polymer can self-

assemble in water to form lipid bilayer or micelles for preparation of liposomes/nanoparticles in drug

delivery, such as mRNA vaccine. The NHS is reactive with protein/peptide or other amine molecule to form

a stable amide linkage.

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Stearic acid-PEG-NHS

BP-26272

Stearic acid-PEG-NHS, MW 1,000

100, 250, 500mg & 1g

Stearic acid-PEG-NHS, MW 1,000 is an amine reactive polyPEG. The polymer is a self-assembling reagent

which forms micelles in aqueous solution and can be used as drug carrier (nanoparticles). The reaction

between NHS ester and amine forms a stable amide linkage.

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BP-26273

Stearic acid-PEG-NHS, MW 2,000

100, 250, 500mg & 1g

Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous

solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond.

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BP-26274

Stearic acid-PEG-NHS, MW 3,400

100, 250, 500mg & 1g

Stearic acid-PEG-NHS, MW 3,400 is a self-assembling PEG reagent which can spontaneously form

micelles in water. Succinimidyl (NHS) group is a good leaving group. The PEG polymer that can react with

nucelophile, such as an amine molecule.

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BP-26275

Stearic acid-PEG-NHS, MW 5,000

100, 250, 500mg & 1g

Stearic acid-PEG-NHS, MW 5,000 is an amphiphile bioconjugation polymer which is reactive with

nucleophile, such as amine, to form a stable amide bond. The polymer forms micelles spontaneously in

water and can be used as drug nanocarrier in targeted drug delivery system.

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Fmoc-N-amido-PEG-NHS ester

BP-25212

Fmoc-N-amido-PEG-NHS ester, MW 2,000

1g & 5g

Fmoc-N-amido-PEG-NHS ester, MW 2,000 is a PEGylation reagent containing a Fmoc protecting group and

a terminal succinimidyl group. NHS ester is reactive with amine nucleophile very rapidly at pH 7-9. The

hydrophilic PEG chain increases the water solubility properties of the compound. The Fmoc group can be

deprotected under basic condition to obtain the free amine which can be used for further conjugations.

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Fmoc-N-amido-PEG-Succinimidyl Valerate

BP-25213

Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400

1g & 5g

Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400 is an amine-protected PEG polymer with a

succinimidyl group. The molecule can react with amine group of lysine or other amino molecule. The Fmoc

group can be deprotected under basic condition to obtain the free amine for further conjugations. The PEG

spacer is hydrophilic and therefore increases the water solubility properties of the compound.

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m-PEG-NHS ester

BP-24177

m-PEG-NHS ester, MW 5,000   

1g

m-PEG-NHS ester, MW 5,000 is an amine reactive PEG polymer. The NHS ester is reactive with primary

amines (-NH2) of proteins, amine-modified oligonucleotides, and other amino molecules.

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BP-24293

m-PEG-NHS ester, MW 10,000

1g

m-PEG-NHS ester, MW 10,000 is an active ester PEG polymer. Coupling between NHS and -NH2 is used for

PEGylation, protein labeling, surface modification, therapeutic nanocarrier etc.

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BP-24311

m-PEG-NHS ester, MW 20,000

1g

m-PEG-NHS ester, MW 20,000 is a PEG polymer with an NHS ester terminal to be reacted with an amine for

protein, peptide, enzyme modification (PEGylation).

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m-PEG-Lys-NHS ester

BP-23761

m-PEG-Lys-NHS ester, MW 20,000

1g & 5g

m-PEG-Lys-NHS ester, MW 20,000 is a PEG polymer NHS ester which can react with primary amine for

labeling proteins and antibodies.

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BP-23762

m-PEG-Lys-NHS ester, MW 40,000

1g & 5g

m-PEG-Lys-NHS ester, MW 40,000 is an NHS ester polyPEG. It is reactive with amino group of protein or

other molecule for labeling application.

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