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작성일 : 22-04-25
[BroadPharm] Polymer PEG, Aldehyde

 

Polymer PEG (Polydisperse PEG)

 

Polymer PEG is a Polyethylene glycol (PEG) polymer with an averaged molecular weight, such as 2K, 5K,

10K, 20K with PDI ranging from 1.01-1.10. Polymer PEG is also known as polydisperse PEG, or Poly-PEG.

There are different shapes of Polymer PEG, such as linear, Y-shaped, branched, or star shaped with

different PEG chain lengths as shown in Figure 1. PEG chain can be attached with different functional groups

for chemistry modification and industrial application.

 

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Figure 1. Examples of Polymer PEG that are commercially available. Typical functional groups include

Acrylate, alkyne, Amine, Azide, DBCO, TCO, Aldehyde, Acid, NHS ester, Hydrazide, Maleimide, Silane,

Biotin, Tos, or Thiol.

 

Polymer PEG have become especially attractive tools in various pharmaceutical, biological and chemical

industry application due to its aqueous solubility, high flexibility and non-immunogenicity

  

 

Polymer PEG, Aldehyde

 

Aldehyde-terminated polyPEG can react with N-terminal of peptide/protein or amino molecule via Schiff base

reaction to yield an imine bond.

 

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m-PEG-Propionaldehyde

Catalog No.

Product Name

Size

Feature

Structure

BP-25285

m-PEG-Propionaldehyde, MW 5,000

1g & 5g

m-PEG-Propionaldehyde, MW 5,000 is an aldehyde PEGylation reagent which is reactive with hydrazide or

aminooxy groups for biomolecular probes and labeling. The hydrophilic PEG chain increases the water

solubility of the compound in aqueous media.

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BP-25282

m-PEG-Propionaldehyde, MW 20,000

1g & 5g

m-PEG-Propionaldehyde, MW 20,000 is an aldhehyde functionalized PEG polymer. Propionaldehyde reacts

with hydrazide or aminooxy compound to form a hydrazone bond and an oxime bond respectively.

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m-PEG-Butyraldehyde

BP-25263

m-PEG-Butyraldehyde, MW 2,000

1g & 5g

m-PEG-Butyraldehyde, MW 2,000 is an aldhehyde functionalized polyPEG. Butyraldehyde reacts with

hydrazide to form a stable hydrazone linkage or with alkoxyamines to form a stable oxime bond. The

hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

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BP-23396

m-PEG-Butyraldehyde, MW 5,000

500mg & 1g

m-PEG-Butyraldehyde, MW 5,000 is a PEG polymer with an aldehyde which is reactive with hydrazide or

aminooxy groups for biomolecular probes and labeling. The hydrophilic PEG chain increases the water

solubility of the compound in aqueous media.

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BP-25261

m-PEG-Butyraldehyde, MW 10,000

1g & 5g

m-PEG-Butyraldehyde, MW 10,000 is a PEG polymer with an aldehyde end group which is commonly used

in PEGylation process due to its reactivity with hydrazide or terminal amine of proteins, antibodies,

hormones, and polypetides.

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BP-25262

m-PEG-Butyraldehyde, MW 20,000

1g & 5g

m-PEG-Butyraldehyde, MW 20,000 is a PEG polymer with an aldehyde moiety which enables reaction with

hydrazide forming hydrazone bond and with N-terminal of proteins to form an imine bond in bioconjugation

processes. 

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BP-25264

m-PEG-Butyraldehyde, MW 30,000

1g & 5g

m-PEG-Butyraldehyde, MW 30,000 is an aldehyde PEG polymer which is reactive with hydrazide or amine

to form a hydrazone or imine bond respectively. The hydrophilic PEG chain increases the water solubility of

the compound in aqueous media.

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PEG-bis-Butyraldehyde

BP-25299

PEG-bis-Butyraldehyde, MW 3,400

1g & 5g

PEG-bis-Butyraldehyde, MW 3,400 is a PEG polymer with two aldehyde groups and is reactive with

hydrazide or amine group to form a stable hydrazone or imine bond respectively.DSPE-PEG-Ald, MW 1,000

is a PEG polymer with hydrophilic phosphate head and hydrophobic lipid tails. The polymer can self-

assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a drug nanocarrier for

administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. The

aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a

reversible imine bond. 

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DSPE-PEG-Aldehyde

BP-26183

DSPE-PEG-Ald, MW 1,000

100, 250 & 500mg

DSPE-PEG-Ald, MW 1,000 is a PEG polymer with hydrophilic phosphate head and hydrophobic lipid tails.

The polymer can self-assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a

drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA

vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to

form a reversible imine bond.

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BP-26184

DSPE-PEG-Ald, MW 2,000

100, 250 & 500mg

DSPE-PEG-Ald, MW 2,000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in

aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for

administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to

form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond.

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BP-26185

DSPE-PEG-Ald, MW 3,400

100, 250 & 500mg

DSPE-PEG-Ald, MW 3,400 is a self-assemble polyPEG which spontaneously forms lipid bilayer in water.

The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA

vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to

form a reversible imine bond.

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BP-26186

DSPE-PEG-Ald, MW 5,000

100, 250 & 500mg

DSPE-PEG-Ald, MW 5,000 is a phospholipid PEG polymer which can self-assemble spontaneously in water

with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare

liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid

nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime

linkage or with amine at pH < 7 to form a reversible imine bond.

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4 arm-PEG-Propionaldehyde

BP-25169

4 arm-PEG-Propionaldehyde, MW 10,000

1, 2 & 5g

4 arm-PEG-Propionaldehyde, MW 10,000 is a multiarm PEG polymer with four terminal aldehydes which is

reactive to hydrazide and aminooxy to form hydrazone bond and oxime bond respectively.

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