Rac Inhibitors
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Rac Inhibitors
Product Name: NSC23766 Hydrochloride – Rac1 Inhibitor
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A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. |
Details
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Chemical Formula: |
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C24H35N7*3HCl. |
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CAS No.: |
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1177865-17-6 |
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Molecular weight: |
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530.96 |
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Purity: |
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99% by HPLC |
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Appearance: |
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White solid |
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Chemical name: |
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N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |
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Solubility: |
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water |
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Storage: |
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Protect from light. Packaged under inert gas |
References
1. Desire, L., et al. J. Biol. Chem. 2005, 280, 37516;
2. Gao, Y., et al. Proc. Natl. Acad. Sci. USA 2004, 101, 7618.
Ordering information
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Catalog No. |
Product Name |
Size |
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CD0192 |
NSC23766 Hydrochloride – Rac1 Inhibitor |
1mg, 5mg, 10mg, 25mg, 50mg, 100mg, 250mg, 500mg & 1g |
▣ 관련 페이지 ; Chemdea
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