AMPK ligands
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AMPK ligands
Product Name: D942 - AMPK Activator
A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by
inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6
myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible
cytotoxicity at pharmacological doses.
Details
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Chemical Formula:
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C22H21FO4
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CAS No.:
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849727-81-7
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Molecular weight:
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368.4
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Purity:
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99% by HPLC
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Appearance:
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Light yellow solid
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Chemical name:
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5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid
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Solubility:
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DMSO (10mg/mL)
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Storage:
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Protect from light. Packaged under inert gas
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References
Product Name: Dorsomorphin (Compound C) – AMPK Inhibitor
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCq, PKA, or JAK3. Blocks celluar activities induced by AICAr or Metformin. Induces weight loss by
attenuating AMPK-mediated food intake in mice.
Details
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Chemical Formula:
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C24H25N5O
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CAS No.:
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866405-64-3
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Molecular weight:
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399.5
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Purity:
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99% by HPLC
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Appearance:
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lLight yellow solid
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Chemical name:
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6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine
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Solubility:
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DMSO (4 mg/mL). The dihydrochloride form of this product (Cat# CD0339) has improved aqueous solubility.
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Storage:
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Protect from light. Packaged under inert gas
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References
Product Name: Dorsomorphin (Compound C) Dihydrochloride – AMPK Inhibitor
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCq, PKA, or JAK3. Blocks celluar activities induced by AICAr or Metformin. Induces weight loss by
attenuating AMPK-mediated food intake in mice.
Details
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Chemical Formula:
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C24H25N5O*HCl
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CAS No.:
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1219168-18-9
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Molecular weight:
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472.41
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Purity:
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99% by HPLC
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Appearance:
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Light yellow solid
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Chemical name:
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6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine dihydrochloride
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Solubility:
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DMSO (5 mg/mL) and water (50 mg/mL). Dorsomorphin dihydrochloride has improved water solubility as compared to the free base form (Cat# CD0185).
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Storage:
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Protect from light. Packaged under inert gas
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References
Ordering informations
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Catalog No.
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Product Name
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Size
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CD0219
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D942 - AMPK Activator
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1mg, 5mg, 10mg, 25mg, 50mg & 100mg
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CD0185
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Dorsomorphin (Compound C)
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1mg, 5mg, 10mg, 25mg,
50mg, 100mg & 250mg
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CD0339
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Dorsomorphin (Compound C) Dihydrochloride
– AMPK Inhibitor
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1mg, 5mg, 10mg, 25mg,
50mg, 100mg & 250mg
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▣ 관련 페이지 ; Chemdea
- 이전글ATM ligands, KU-55933 - ATM Kinase Inhibitor 14.01.10
- 다음글Kinase & ATP binding proteins enrichment reagents 14.01.08
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