Products

Obtustatin, Inhibitor of the binding of α₁β₁ integrin to collagen IV

Desintegrins are potent inhibitors of integrin cell-dependent adhesion

 

 

Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a

potent (IC₅₀ = 2 nM) and selective inhibitor of the binding of α₁β₁ integrin to collagen IV. Contrary to other

known disintegrinse, it does not contain the classical RGD sequence. Obtustatin does not show inhibitory

activity toward other integrins, including α₂β₁, α_IIbβ₃, α_vβ₃, α₄β₁, α₅β₁, α₆β₁, and α₉β₁, α₄β₇ integrins. 

Obtustatin potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development

by half.

 

Details

AA sequence:		Cys1-Thr-Thr-Gly-Pro-Cys6-Cys7-Arg-Gln-Cys10-Lys-Leu-Lys-Pro-Ala- Gly-Thr-Thr-Cys19-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys29-Thr-Gly- Lys-Ser-Cys34-Asp-Cys36-Pro-Leu-Tyr-Pro-Gly-OH
Disulfide bonds:		Cys1-Cys10, Cys6-Cys29, Cys7-Cys34 and Cys19-Cys36
Length (aa):		41
Formula:		C184H284N52O57S8
Molecular Weight:		4393.13. Da
Appearance:		White lyophilized solid
Solubility:		Aqueous buffer
Source:		Synthetic
Purity rate		> 97 %

 

 

Reference

1. Daidone I, et al. (2013) Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and Lebestatin. Biopolymers. PMID: 23097229