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Doxoves™ - Liposomal Doxorubicin HCl, New 2mg/mL

Doxoves™ - Liposomal Doxorubicin HCl, New 2mg/mL

항종양 활성을 갖는 항생물질 Doxorubicin HCl을 내포한 liposome입니다. Doxorubicin HCl을 liposome 내에 내포

시킴으로써 pharmacokinetics/pharmacodynamics(PK/PD)적인 작용이 개선됩니다.

입경이 균일하기 때문에 lot 간의 차이가 적은 고품질로서, 높은 봉입 효율을 보이도록 조제되어 있습니다.

Doxorubicin HCl이 없는 control용 liposome도 있습니다.

* Doxorubicin은, reverse transcriptase, RNA polymerase의 활성을 억제하는 항생물질입니다. Intercalation에

의해 이중 가닥 DNA에 결합하여, DNA의 복제·전사를 억제하는 것으로 생각되고 있으며, 세포 사멸을 유도합니다.

Cryo-EM of FormuMax's liposome doxorubicin HCl (F30204B-D) (Image taken by NanoImaging Services Inc.)

FormuMax has been providing custom-made formulations of liposomal doxorubicin HCl with various lipid

compositions and particle sizes. There has been an increased demand of liposomal doxorubicin

comparable to the commercial Doxil. Now we are proudly naming our product, Doxoves, and making it

available to you at an affordable price.

Doxoves is manufactured to high quality with consistent lot-lot characteristics, tight particle size distribution

and high drug encapsulation efficiency. A high drug concentration of 4.0 mg/mL (40mM lipid) allows

researchers to perform experiments athigher concentrations/doses. Doxoves is comparable to the

commercial product Doxil in characteristics, stability and pharmacokinetics. Cryo-TEM studies have

shown that the encapsulated doxorubicin forms the same type of rod-like structures as in Doxil. A recent

PK study of two batches of Doxoves demonstrated an excellent PK profile with t1/2 of 30-40hr similar to that

of Doxil.

Good News !!!

According to request from customers, the 2.0mg/mL liposomal doxorubicin HCl is now available.

Ordering informations

Catalog No.	Product Name	Size
F30204C-D	Combo kit of Doxoves and the plain control liposomes	2 ml & 10 ml
F30204B-C	Control liposomes for Doxoves(4.0mg/mL)	2 ml & 10 ml
F30204B-C2	Control liposomes for Doxoves(2.0mg/mL)	2 ml & 10 ml
F30204B-D	Doxoves - STEALTH Liposomal Doxorubicin HCl (4.0mg/mL)	2 ml & 10 ml
F30204B-D2	Doxoves - STEALTH Liposomal Doxorubicin HCl (2.0mg/mL)	2 ml & 10 ml
FB30020	Dilution Buffer for Doxoves™	2 ml & 10 ml

▣ 관련 페이지 ; FormuMax Scientific

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