화학합성의 Calcium Channel Blocker Peptide Toxin(2)
본문
화학합성의 각종 Calcium Channel Blocker Peptide Toxin (2)
Calcium channel 연구에 유용한 유독 생물 유래의 합성 peptide toxin 입니다. 화학합성 peptide이기 때문에
endotoxin 오염의 걱정이 없습니다.
Maurocalcine
Maurocalcine is a component of the venom of Scorpio maurus palmatus. It folds according to an inhibitor cysteine knot. It
is a new member of the family of toxins acting on ryanodine receptors with an affinity in the 10 nM range. It induces an
increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. It has
also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular
perfusion.
Details
|
AA sequence: |
|
H-Gly-Asp-Cys3-Leu-Pro-His-Leu-Lys-Leu-Cys10-Lys-Glu-Asn-Lys-Asp-Cys16-Cys17-Ser-Lys-Lys-
Cys21-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys32-Arg-OH |
|
|
|
(Disulfide bonds between Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32) |
|
Length (aa): |
|
33 |
|
Formula: |
|
C156H260N56O46S6 |
|
Molecular Weight: |
|
3858.8 Da |
|
Appearance: |
|
White lyophilized solid |
|
Solubility: |
|
Water and saline buffer |
|
CAS number: |
|
Not available |
|
Source: |
|
Synthetic |
|
Purity rate: |
|
> 98 % |
References
1. Fajloun, Z., et al. (2000) Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates
Ca(2+) release channel/ryanodine receptors, FEBS Lett. PubMed link
2. Mosbah, A., et al. (2000) A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive
calcium channel, Proteins. PubMed link
Huwentoxin I
Huwentoxin I is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider) (Ornithoctonus
huwenum). This toxin selectively inhibits N-type calcium channels and has only a very weak effect on L-type calcium
channels. It has virtually no effect on muscle sodium channels but is a potent inhibitor of neuronal TTX-sensitive
channels, especially Nav1.7.
Details
|
AA sequence: |
|
H-Ala-Cys2-Lys-Gly-Val-Phe-Asp-Ala-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Arg-
Val-Cys22-Ser-Asp-Lys-His-Lys-Trp-Cys26-Lys-Trp-Lys-Leu-OH |
|
|
|
(Disulfide bonds between Cys2-Cys17, Cys9-Cys22, and Cys16-Cys29) |
|
Length (aa): |
|
33 |
|
Formula: |
|
C168H250N46O41S6 |
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Molecular Weight: |
|
3751.77 Da |
|
Appearance: |
|
White lyophilized solid |
|
Solubility: |
|
Water and saline buffer |
|
CAS number: |
|
Not available |
|
Source: |
|
Synthetic |
|
Purity rate: |
|
> 97 % |
References
1. Wang M, et al. (2007) The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion
neurons. Biochem Biophys Res Commun. PubMed link
2. Wang YR, et al. (2007) Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with
global cerebral ischemia. Toxicon. PubMed link
3. Peng, K., et al. (2001) The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells,
4. Liang, S. P., et al. (2000) The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird
spider Selenocosmia huwena, Toxicon. PubMed link
5. Zhou, P. A., et al. (1997) Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the
6. Liang, S. P., et al. (1993) Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom
of the Chinese bird spider Selenocosmia huwena, Toxicon. PubMed link
ω CONOTOXIN SO-3 / Omega contoxin SO-3
ω-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This peptide
selectively targets N-type voltage-sensitive calcium channels. It has no effect on R-type calcium currents, voltage-
sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. It displays an
analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects
compared with identical dosages of MVIIA injected intrathecally.
Details
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AA sequence: |
|
H-Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-
Arg-Ser-Gly-Lys-Cys25-NH2 |
|
|
|
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25) |
|
Length (aa): |
|
25 |
|
Formula: |
|
C100H165N35O32S6 |
|
Molecular Weight: |
|
2657.07 Da |
|
Appearance: |
|
White lyophilized solid |
|
Solubility: |
|
Water and saline buffer |
|
CAS number: |
|
Not available |
|
Source: |
|
Synthetic |
|
Purity rate: |
|
> 97 % |
References
1. Wen, L., et al. (2005) SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits
2. Li, Z., et al. (2003) Effect of new O-superfamily conotoxin SO3 on sodium and potassium currents of cultured
hippocampal neurons, Brain Res. PubMed link
ω-Conotoxin MVIIA / Omega conotoxin MVIIA
(Ziconotide)
ω-Conotoxin MVIIA has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic
membranes, they bind and block voltage-sensitive calcium channels (VSCC). This toxin blocks N-type calcium channels
(Cav2.2/CACNA1B). ω-conotoxin MVIIA is available under the name Prialt by Neurex. It blocks acute pain in patients who
no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium
channels and disables nerves that transmit pain signals.
Details
|
AA sequence: |
|
Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-
Arg-Ser-Gly-Lys-Cys25-NH2 |
|
|
|
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25 ) |
|
Length (aa): |
|
25 |
|
Formula: |
|
C102H172N36O32S7 |
|
Molecular Weight: |
|
2639.18 Da |
|
Appearance: |
|
White lyophilized solid |
|
Solubility: |
|
Water and saline buffer |
|
CAS number: |
|
107452-89-1 |
|
Source: |
|
Synthetic |
|
Purity rate: |
|
> 97 % |
References
1. Miljanich, G. P. (2004) Ziconotide: neuronal calcium channel blocker for treating severe chronic pain, Curr Med Chem.
2. Olivera, B. M., et al. (1987) Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes
using omega-conotoxin from Conus magus venom, Biochemistry. PubMed link
3. Bowersox SS, Luther R. Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal
calcium channel blocker found in the venom of Conus magus. Toxicon. PubMed link
Ordering informations
|
Catalog No. |
Product Name |
Size |
|
07MAU001 |
Maurocalcine |
0.1mg, 0.5mg & 1.0mg |
|
07HWT001 |
Huwentoxin I |
0.1mg, 0.5mg & 1.0mg |
|
08CON013 |
ω CONOTOXIN SO-3 |
0.1mg, 0.5mg & 1.0mg |
|
08CON001 |
ω-Conotoxin MVIIA |
0.1mg, 0.5mg & 1.0mg |
* 다른 사이즈나 bulk 공급도 가능하오니 별도로 문의하여 주십시오.
* 관련 제품
ω-agatoxin IVA / ω-CONOTOXIN GVIA/Omega conotoxin GVIA / ω-Conotoxin MVIIC/Omega conotoxin MVIIC / SNX482
▣ 관련 페이지 ; Smartox Biotechnology
• 화학 합성의 각종 TRP Channel Blocker Peptide Toxin
GsMTx4 / Vanillotoxin-3 (VaTx3)
• 화학 합성의 각종 ASIC Channel Blocker Peptide Toxin
Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) / APETx2
• 화학 합성의 각종 Chloride Channel Blocker Peptide Toxin
GaTx1 / GaTx2 / Chlorotoxin
• 화학 합성의 각종 Calcium Channel Blocker Peptide Toxin
ω-agatoxin IVA / ω-CONOTOXIN GVIA/Omega conotoxin GVIA / ω-Conotoxin MVIIC/Omega conotoxin MVIIC /
SNX482/ Maurocalcine/Huwentoxin I/ω CONOTOXIN SO-3/Omega contoxin SO-3/ω-Conotoxin MVIIA/
Omega conotoxin MVIIA
• 화학 합성의 각종 Potassium Channel Blocker Peptide Toxin
Iberiotoxin (IbTx) / Charybdotoxin / Leiurotoxin 1 / Tamapin / Guangxitoxin 1E / ShK (Stichodactyla toxin)/
Margatoxin / HsTx1 / Apamin / TERTIAPIN-Q / Maurotoxin / Kaliotoxin-1
• 화학 합성의 각종 Sodium Channel Blocker Peptide Toxin
Protoxin I (ProTx-1) / GsAF-I / GsAF-II / Jingzhaotoxin III / Biotinyl-Protoxin II (ProTx II) / Hainantoxin-IV /
Protoxin II (ProTx II) / Huwentoxin IV / Huwentoxin I / μ Conotoxin PIIIA / mu conotoxin PIIIA
- 이전글화학합성의 Chloride Channel Blocker Peptide Toxin(1) 13.06.11
- 다음글화학합성의 Calcium Channel Blocker Peptide Toxin(1) 13.05.29
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