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Betulin & derivatives

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Betulin & derivatives

 

Betulin and derivatives are pentacyclic lupane-type triterpenoids and are widely distributed throughout the

plant kingdom. They exhibit a variety of biological and medicinal properties such as inhibition of human

immunodeficiency vir us (HIV), anti-bacterial, anti-malarial, anti-inflammatory anthelmintic,

immunomodulatory, anti-fibrotic, antinociceptive, anti HSV 1, and anticancer activities. The growth of cancer

cells is inhibited, without affecting normal cells and its lack of cytot oxic activity has been demonstrated in

human astrocytes, human dermal fibroblasts, peripheral blood lymp fibroblasts, peripheral blood

lymphoblasts and animal studies. The cytotoxicity and mode of cell death were determined using the MTT

assay and DNA frag mentation analysis, respectively. Cells treated with high concentrations exhibited

features characteristic of apoptosis such as blebbing and shrinking. Combined treatment with Betulin

derivatives and anticancer drugs acted in concert to induce loss of mito chondrial membrane potential and

the release of cytochrome C and Smac from mitochondria, resulting in activation of Caspases and

apoptosis.

 

Compounds with lupane structure typically exhibit limited solubility in organic solvents such as methanol

and ethanol, chloroform, and ether and has low solubility in water, petroleum ether, dimethyl formamide,

dimethyl sulfoxide, and benzene. However, they are normally highly soluble in pyridine and acetic acid.

 

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Name

 Cas No.

Formula

M.W

 Betulin

473-98-3

C30H50O2

442.73 g/mol

 Betulin 3,28-diacetate

1721-69-3

C34H54O4

526.79 g/mol

 Betulinaldehyde

13159-28-9

C30H48O2

440.7 g/mol

 Betulinic acid

 472-15-1

C30H48O3

456.7 g/mol

 Betulinic amido-DOOA-Mal

N/A

C40H62N2O6

666.94 g/mol

 Betulinic amido-TOTA-Mal

N/A

 C44H72N2O7

739.05 g/mol

 Betulinic amido-DOOA-azide

N/A

C36H60N4O4

612.89 g/mol

 Betulinaldehyde oxime

25613-12-1

C30H49NO2

455.72 g/mol

 Betulinic glycine amide

174740-40-0

C32H51NO4

513.75 g/mol

 Betulinic acid ethyl ester

189384-88-1

C32H52O3

484.75 g/mol

 Betulinic acid methyl ester

2259-06-5

C31H50O3

470.73 g/mol

 3-Oxobetulin

7020-34-0

C30H48O2

440.7 g/mol

 Dihydrobetulin

7372-31-8

C30H52O2

444.73 g/mol

 3-Acetylbetulin

27570-20-3

C32H52O3

484.75 g/mol

 28-Aminobetulin

25613-16-5

C30H51NO

441.73 g/mol

 28-Acetylbetulin

27686-35-7

C32H52O3

484.75 g/mol

 3-Oxobetulin acetate

136587-07-0

C32H50O3

482.74 g/mol

 2,3-Indolobetulin

2365493-59-8

C36H51NO

513.81 g/mol

 Dihydrobetulinaldehyde

911140-88-0

C30H52O2

442.72 g/mol

 3-Acetylbetulinaldehyde

27570-21-4

C32H50O3

482.74 g/mol

 Dihydrobetulin diacetate

43124-92-1

C34H56O6

528.81 g/mol

 28-(Boc-amino)betulin

N/A

C35H59NO3

541.86 g/mol

 N-(2-Mal-ethyl)betulin amide

N/A

C32H54N2O4

578.84 g/mol

 N-(2-Poc-ethyl)betulin amide

N/A

C32H56N2O4

580.85 g/mol

 2,3-Indolobetulinic glycine amide

905838-14-4

C38H52N2O3

584.83 g/mol

 N-(2-Azidoethyl)betulin amide

N/A

C32H52N4O2

524.79 g/mol

 3-Acetyldihydro betulinaldehyde

134502-01-5

C32H52O3

484.75 g/mol

 Betulonic acid

4481-62-3

C30H46O3

454.68 g/mol

 Betulonic acid ethyl ester

N/A

C32H50O3

482.74 g/mol

 Betulonic acid methyl ester

4356-31-4

C31H48O3

468.71 g/mol

 Betulonamide

628308-25-8

C30H47NO2

453.7 g/mol

 Betulonaldehyde

4439-98-9

C30H46O2

438.69 g/mol

 2,3-Indolobetulonic acid

905837-93-6

C32H49NO2

527.78 g/mol

 

 

Ordering informations

   

Catalog No.

Product Name

Size

LSB3001

Betulin

10,  25, 50 & 100 g

LSB3036

Betulin 3,28-diacetate

5, 10, 25 & 50 g

LSB3037

Betulinaldehyde

1, 2.5, 5 & 10 g

LSB5008

Betulinic acid

1, 2.5, 5 & 10 g

LSB7024

Betulinic amido-DOOA-Mal

50, 100, 250 & 500 mg

LSB7023

Betulinic amido-TOTA-Mal

50, 100, 250 & 500 mg

LSB7022

Betulinic amido-DOOA-azide

50, 100 & 250 mg

LSB3038

Betulinaldehyde oxime

1, 2.5, 5 & 10 g

LSB2017

Betulinic glycine amide

1, 2.5, 5 & 10 g

LSB2019

Betulinic acid ethyl ester

1, 2.5, 5 & 10 g

LSB2018

Betulinic acid methyl ester

1, 2.5, 5 & 10 g

LSB3039

3-Oxobetulin

1, 2.5, 5 & 10 g

LSB3030

Dihydrobetulin

1, 2.5, 5 & 10 g

LSB3018

3-Acetylbetulin

1, 2.5, 5 & 10 g

LSB1012

28-Aminobetulin

1, 2.5, 5 & 10 g

LSB3034

28-Acetylbetulin

1, 2.5, 5 & 10 g

LSB3035

3-Oxobetulin acetate

1, 2.5, 5 & 10 g

LSB3040

2,3-Indolobetulin

1, 2.5, 5 & 10 g

LSB3033

Dihydrobetulinaldehyde

1, 2.5, 5 & 10 g

LSB3020

3-Acetylbetulinaldehyde

1, 2.5, 5 & 10 g

LSB3031

Dihydrobetulin diacetate

1, 2.5, 5 & 10 g

LSB1013

28-(Boc-amino)betulin

1, 2.5, 5 & 10 g

LSB7025

N-(2-Mal-ethyl)betulin amide

50, 100, 250 & 500 mg

LSB7027

N-(2-Poc-ethyl)betulin amide

50, 100, 250 & 500 mg

LSB5016

2,3-Indolobetulinic glycine amide

1, 2.5, 5 & 10 g

LSB7026

N-(2-Azidoethyl)betulin amide

50, 100, 250 & 500 mg

LSB3016

3-Acetyldihydro betulinaldehyde

1, 2.5, 5 & 10 g

LSB5009

Betulonic acid

1, 2.5, 5 & 10 g

LSB5013

Betulonic acid ethyl ester

1, 2.5, 5 & 10 g

LSB5012

Betulonic acid methyl ester

1, 2.5, 5 & 10 g

LSB4027

Betulonamide

1, 2.5, 5 & 10 g

LSB3029

Betulonaldehyde

1, 2.5, 5 & 10 g

LSB5014

2,3-Indolobetulonic acid

1, 2.5, 5 & 10 g

 

 

▣ 관련 페이지 ; Iris Biotech GMBH

   

  

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