Products

Lipid_Cationic/Ionizable/Branched/DBCO

Lipid is a class of organic compounds that are fatty acids or their derivatives that are insoluble in water but

soluble in organic solvents. They include many natural oils, waxes, and steroids or their derivatives.

The functions of lipids include storing energy, signaling, and acting as structural components of cell

membranes. Lipids have become widely used in the cosmetic and food industries as well as in nanoparticle

drug technology. The amphiphilic nature of some lipids allows them to form structures such as vesicles,

multilamellar/unilamellar liposomes, or membranes in an aqueous environment.

There are four main kinds of lipids used in lipid nanoparticle (LNP) drug delivery vehicle. Cationic Lipid,

Ionizable Lipid, PEG lipid, Helper Lipid.

Cationic Lipid

Cationic lipids neutralize negative charges, facilitate encapsultation, and cell uptake in lipid nanoparticle (LNP) .

Ionizable Lipid

Ionizable Lipids promote endosome escape and reduce toxicity of lipid nanoparticle (LNP).

Branched Lipid

Branched lipid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in

vivo. This includes siRNA to induce gene silencing in a sequence-specific manner, CAS9 mRNA, and

cytotoxic proteins.

Lipid-DBCO