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Cleavable Linkers, β-Glucuronide Linkers

Cleavable Linkers, β-Glucuronide Linkers

β-Glucuronide Linkers is an enzyme-labile linker used in the development of antibody-drug conjugates. The

β-Glucuronide and cytotoxic drug conjugate complex undergoes cleavage by β-glucuronidase and releases

the cytotoxic drug. β-glucuronidase is an enzyme present in lysosomes and over expressed in some

tumors.

Unlike dipeptide-based ADCs that are prone to aggregation, β-glucuronide linkers have hydrophilic properties

that may potentially reduce aggregation of the hydrophobic drugs and promote the solubility of intact

antibody-drug conjugates.

Catalog No.	Product Name	M.W	Purity	Size
Structure
AP10901	β-D-triacetylglucopyranosiduronyl methyl ester- phenol-β-Alanine	748.73	≥95%	100mg & 250mg

AP10975	β-tetraacetylglucopyranoside-glycerol	422.38	≥95%	250mg, 500mg & 1g

AP10974	β-tetraacetylglucopyranoside-glycol	392.36	≥95%	500mg & 1g

AP10153	(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)- 4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate	913.83	≥95%	100mg, 250mg, 500mg & 1g

AP10152	4-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate	483.38	≥95%	100mg, 250mg, 500mg & 1g

AP10154	β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl) phenyl, methyl ester, 2,3,4-triacetate	455.41	≥95%	100mg, 250mg, 500mg & 1g

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