Polymer PEG (Polydisperse PEG)
Polymer PEG is a Polyethylene glycol (PEG) polymer with an averaged molecular weight, such as 2K, 5K,
10K, 20K with PDI ranging from 1.01-1.10. Polymer PEG is also known as polydisperse PEG, or Poly-PEG.
There are different shapes of Polymer PEG, such as linear, Y-shaped, branched, or star shaped with
different PEG chain lengths as shown in Figure 1. PEG chain can be attached with different functional groups
for chemistry modification and industrial application.
Figure 1. Examples of Polymer PEG that are commercially available. Typical functional groups include
Acrylate, alkyne, Amine, Azide, DBCO, TCO, Aldehyde, Acid, NHS ester, Hydrazide, Maleimide, Silane,
Biotin, Tos, or Thiol.
Polymer PEG have become especially attractive tools in various pharmaceutical, biological and chemical
industry application due to its aqueous solubility, high flexibility and non-immunogenicity
Polymer PEG, Active ester
NHS ester-activated PEGylation polymer can react with primary amines at pH 7.2 to 9 to yield a stable
(covalent) amide bond. The reaction releases N-hydroxysuccinimide (NHS). Nucleophilic reaction between
amine and active ester is most commonly performed in phosphate, carbonate-bicarbonate, HEPES or borate
buffers at pH 7.2 to 8.5 for 0.5 to 4 h at room temperature or 4°C.
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