Polymer PEG (Polydisperse PEG)
Polymer PEG is a Polyethylene glycol (PEG) polymer with an averaged molecular weight, such as 2K, 5K,
10K, 20K with PDI ranging from 1.01-1.10. Polymer PEG is also known as polydisperse PEG, or Poly-PEG.
There are different shapes of Polymer PEG, such as linear, Y-shaped, branched, or star shaped with
different PEG chain lengths as shown in Figure 1. PEG chain can be attached with different functional groups
for chemistry modification and industrial application.
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/poly_peg_function_groups_fig_adj.jpg)
Figure 1. Examples of Polymer PEG that are commercially available. Typical functional groups include
Acrylate, alkyne, Amine, Azide, DBCO, TCO, Aldehyde, Acid, NHS ester, Hydrazide, Maleimide, Silane,
Biotin, Tos, or Thiol.
Polymer PEG have become especially attractive tools in various pharmaceutical, biological and chemical
industry application due to its aqueous solubility, high flexibility and non-immunogenicity
Polymer PEG, Active ester
NHS ester-activated PEGylation polymer can react with primary amines at pH 7.2 to 9 to yield a stable
(covalent) amide bond. The reaction releases N-hydroxysuccinimide (NHS). Nucleophilic reaction between
amine and active ester is most commonly performed in phosphate, carbonate-bicarbonate, HEPES or borate
buffers at pH 7.2 to 8.5 for 0.5 to 4 h at room temperature or 4°C.
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/active-ester-diagram_550.jpg)
DSPE-PEG-NHS
Catalog No.
|
Product Name
|
Size
|
Feature
|
Structure
|
BP-26254
|
DSPE-PEG-NHS, MW 600
|
100, 250 & 500mg
|
DSPE-PEG-NHS, MW 600 is a phospholipid PEG which can react with protein/peptide or other amine
molecule. The polymer forms lipid bilayer in an aquoeus solution and can be used to prepare liposomes for
drug delivery application, such as mRNA vaccine or cancer immunotherapy.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26254_adj.gif)
|
BP-26220
|
DSPE-PEG-NHS, MW 1,000
|
100, 250 & 500mg
|
DSPE-PEG-NHS, MW 1,000 is an amine reactive phospholipid. The reaction between NHS ester and amine
forms a stable amide linkage. The polymer is amphiphilic which enables formation of micelles or lipid
bilayer in aqueous solution.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26220_adj.gif)
|
BP-26221
|
DSPE-PEG-NHS, MW 2,000
|
100, 250 & 500mg
|
DSPE-PEG-NHS, MW 2,000 is a phospholipid PEG polymer which can be used to encapsulate
drugs/therapeutics agents in targeted drug delivery system, such as liposome based mRNA vaccine. The
NHS-ester is reactive with amine at pH 6.5 to 7.5 to form a stable amide bond.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26221_adj.gif)
|
BP-26222
|
DSPE-PEG-NHS, MW 3,400
|
100, 250 & 500mg
|
DSPE-PEG-NHS, MW 3,400 is an amine reactive phospholipid which can be used to prepare liposome or
lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26222_adj.gif)
|
BP-26223
|
DSPE-PEG-NHS, MW 5,000
|
100, 250 & 500mg
|
DSPE-PEG-NHS, MW 5,000 is a polydisperse PEG attached with phospholipid. The polymer can self-
assemble in water to form lipid bilayer or micelles for preparation of liposomes/nanoparticles in drug
delivery, such as mRNA vaccine. The NHS is reactive with protein/peptide or other amine molecule to form
a stable amide linkage.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26223_adj.gif)
|
Stearic acid-PEG-NHS
BP-26272
|
Stearic acid-PEG-NHS, MW 1,000
|
100, 250, 500mg & 1g
|
Stearic acid-PEG-NHS, MW 1,000 is an amine reactive polyPEG. The polymer is a self-assembling reagent
which forms micelles in aqueous solution and can be used as drug carrier (nanoparticles). The reaction
between NHS ester and amine forms a stable amide linkage.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26272_adj.gif)
|
BP-26273
|
Stearic acid-PEG-NHS, MW 2,000
|
100, 250, 500mg & 1g
|
Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous
solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26273_adj.gif)
|
BP-26274
|
Stearic acid-PEG-NHS, MW 3,400
|
100, 250, 500mg & 1g
|
Stearic acid-PEG-NHS, MW 3,400 is a self-assembling PEG reagent which can spontaneously form
micelles in water. Succinimidyl (NHS) group is a good leaving group. The PEG polymer that can react with
nucelophile, such as an amine molecule.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26274_adj.gif)
|
BP-26275
|
Stearic acid-PEG-NHS, MW 5,000
|
100, 250, 500mg & 1g
|
Stearic acid-PEG-NHS, MW 5,000 is an amphiphile bioconjugation polymer which is reactive with
nucleophile, such as amine, to form a stable amide bond. The polymer forms micelles spontaneously in
water and can be used as drug nanocarrier in targeted drug delivery system.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-26275_adj.gif)
|
Fmoc-N-amido-PEG-NHS ester
BP-25212
|
Fmoc-N-amido-PEG-NHS ester, MW 2,000
|
1g & 5g
|
Fmoc-N-amido-PEG-NHS ester, MW 2,000 is a PEGylation reagent containing a Fmoc protecting group and
a terminal succinimidyl group. NHS ester is reactive with amine nucleophile very rapidly at pH 7-9. The
hydrophilic PEG chain increases the water solubility properties of the compound. The Fmoc group can be
deprotected under basic condition to obtain the free amine which can be used for further conjugations.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-25212_adj.gif)
|
Fmoc-N-amido-PEG-Succinimidyl Valerate
BP-25213
|
Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400
|
1g & 5g
|
Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400 is an amine-protected PEG polymer with a
succinimidyl group. The molecule can react with amine group of lysine or other amino molecule. The Fmoc
group can be deprotected under basic condition to obtain the free amine for further conjugations. The PEG
spacer is hydrophilic and therefore increases the water solubility properties of the compound.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-25213_adj.gif)
|
m-PEG-NHS ester
BP-24177
|
m-PEG-NHS ester, MW 5,000
|
1g
|
m-PEG-NHS ester, MW 5,000 is an amine reactive PEG polymer. The NHS ester is reactive with primary
amines (-NH2) of proteins, amine-modified oligonucleotides, and other amino molecules.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-24177_adj.gif)
|
BP-24293
|
m-PEG-NHS ester, MW 10,000
|
1g
|
m-PEG-NHS ester, MW 10,000 is an active ester PEG polymer. Coupling between NHS and -NH2 is used for
PEGylation, protein labeling, surface modification, therapeutic nanocarrier etc.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-24293_adj.gif)
|
BP-24311
|
m-PEG-NHS ester, MW 20,000
|
1g
|
m-PEG-NHS ester, MW 20,000 is a PEG polymer with an NHS ester terminal to be reacted with an amine for
protein, peptide, enzyme modification (PEGylation).
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-24311_adj.gif)
|
m-PEG-Lys-NHS ester
BP-23761
|
m-PEG-Lys-NHS ester, MW 20,000
|
1g & 5g
|
m-PEG-Lys-NHS ester, MW 20,000 is a PEG polymer NHS ester which can react with primary amine for
labeling proteins and antibodies.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-23761_adj.gif)
|
BP-23762
|
m-PEG-Lys-NHS ester, MW 40,000
|
1g & 5g
|
m-PEG-Lys-NHS ester, MW 40,000 is an NHS ester polyPEG. It is reactive with amino group of protein or
other molecule for labeling application.
|
![클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요](http://www.sambomed.co.kr/jboard/data/data/binary/BP-23762_adj.gif)
|
|