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Polymer PEG (Polydisperse PEG)
Polymer PEG is a Polyethylene glycol (PEG) polymer with an averaged molecular weight, such as 2K, 5K,
10K, 20K with PDI ranging from 1.01-1.10. Polymer PEG is also known as polydisperse PEG, or Poly-PEG.
There are different shapes of Polymer PEG, such as linear, Y-shaped, branched, or star shaped with
different PEG chain lengths as shown in Figure 1. PEG chain can be attached with different functional groups
for chemistry modification and industrial application.
Figure 1. Examples of Polymer PEG that are commercially available. Typical functional groups include
Acrylate, alkyne, Amine, Azide, DBCO, TCO, Aldehyde, Acid, NHS ester, Hydrazide, Maleimide, Silane,
Biotin, Tos, or Thiol.
Polymer PEG have become especially attractive tools in various pharmaceutical, biological and chemical
industry application due to its aqueous solubility, high flexibility and non-immunogenicity
Polymer PEG, Active ester
NHS ester-activated PEGylation polymer can react with primary amines at pH 7.2 to 9 to yield a stable
(covalent) amide bond. The reaction releases N-hydroxysuccinimide (NHS). Nucleophilic reaction between
amine and active ester is most commonly performed in phosphate, carbonate-bicarbonate, HEPES or borate
buffers at pH 7.2 to 8.5 for 0.5 to 4 h at room temperature or 4°C.
DSPE-PEG-NHS
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Catalog No.
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Product Name
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Size
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Feature
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Structure
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BP-26254
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DSPE-PEG-NHS, MW 600
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100, 250 & 500mg
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DSPE-PEG-NHS, MW 600 is a phospholipid PEG which can react with protein/peptide or other amine
molecule. The polymer forms lipid bilayer in an aquoeus solution and can be used to prepare liposomes for
drug delivery application, such as mRNA vaccine or cancer immunotherapy.
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BP-26220
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DSPE-PEG-NHS, MW 1,000
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100, 250 & 500mg
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DSPE-PEG-NHS, MW 1,000 is an amine reactive phospholipid. The reaction between NHS ester and amine
forms a stable amide linkage. The polymer is amphiphilic which enables formation of micelles or lipid
bilayer in aqueous solution.
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BP-26221
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DSPE-PEG-NHS, MW 2,000
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100, 250 & 500mg
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DSPE-PEG-NHS, MW 2,000 is a phospholipid PEG polymer which can be used to encapsulate
drugs/therapeutics agents in targeted drug delivery system, such as liposome based mRNA vaccine. The
NHS-ester is reactive with amine at pH 6.5 to 7.5 to form a stable amide bond.
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BP-26222
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DSPE-PEG-NHS, MW 3,400
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100, 250 & 500mg
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DSPE-PEG-NHS, MW 3,400 is an amine reactive phospholipid which can be used to prepare liposome or
lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
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BP-26223
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DSPE-PEG-NHS, MW 5,000
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100, 250 & 500mg
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DSPE-PEG-NHS, MW 5,000 is a polydisperse PEG attached with phospholipid. The polymer can self-
assemble in water to form lipid bilayer or micelles for preparation of liposomes/nanoparticles in drug
delivery, such as mRNA vaccine. The NHS is reactive with protein/peptide or other amine molecule to form
a stable amide linkage.
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Stearic acid-PEG-NHS
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BP-26272
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Stearic acid-PEG-NHS, MW 1,000
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100, 250, 500mg & 1g
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Stearic acid-PEG-NHS, MW 1,000 is an amine reactive polyPEG. The polymer is a self-assembling reagent
which forms micelles in aqueous solution and can be used as drug carrier (nanoparticles). The reaction
between NHS ester and amine forms a stable amide linkage.
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BP-26273
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Stearic acid-PEG-NHS, MW 2,000
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100, 250, 500mg & 1g
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Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous
solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond.
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BP-26274
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Stearic acid-PEG-NHS, MW 3,400
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100, 250, 500mg & 1g
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Stearic acid-PEG-NHS, MW 3,400 is a self-assembling PEG reagent which can spontaneously form
micelles in water. Succinimidyl (NHS) group is a good leaving group. The PEG polymer that can react with
nucelophile, such as an amine molecule.
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BP-26275
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Stearic acid-PEG-NHS, MW 5,000
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100, 250, 500mg & 1g
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Stearic acid-PEG-NHS, MW 5,000 is an amphiphile bioconjugation polymer which is reactive with
nucleophile, such as amine, to form a stable amide bond. The polymer forms micelles spontaneously in
water and can be used as drug nanocarrier in targeted drug delivery system.
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Fmoc-N-amido-PEG-NHS ester
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BP-25212
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Fmoc-N-amido-PEG-NHS ester, MW 2,000
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1g & 5g
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Fmoc-N-amido-PEG-NHS ester, MW 2,000 is a PEGylation reagent containing a Fmoc protecting group and
a terminal succinimidyl group. NHS ester is reactive with amine nucleophile very rapidly at pH 7-9. The
hydrophilic PEG chain increases the water solubility properties of the compound. The Fmoc group can be
deprotected under basic condition to obtain the free amine which can be used for further conjugations.
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Fmoc-N-amido-PEG-Succinimidyl Valerate
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BP-25213
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Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400
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1g & 5g
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Fmoc-N-amido-PEG-Succinimidyl Valerate, MW 3,400 is an amine-protected PEG polymer with a
succinimidyl group. The molecule can react with amine group of lysine or other amino molecule. The Fmoc
group can be deprotected under basic condition to obtain the free amine for further conjugations. The PEG
spacer is hydrophilic and therefore increases the water solubility properties of the compound.
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m-PEG-NHS ester
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BP-24177
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m-PEG-NHS ester, MW 5,000
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1g
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m-PEG-NHS ester, MW 5,000 is an amine reactive PEG polymer. The NHS ester is reactive with primary
amines (-NH2) of proteins, amine-modified oligonucleotides, and other amino molecules.
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BP-24293
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m-PEG-NHS ester, MW 10,000
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1g
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m-PEG-NHS ester, MW 10,000 is an active ester PEG polymer. Coupling between NHS and -NH2 is used for
PEGylation, protein labeling, surface modification, therapeutic nanocarrier etc.
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BP-24311
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m-PEG-NHS ester, MW 20,000
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1g
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m-PEG-NHS ester, MW 20,000 is a PEG polymer with an NHS ester terminal to be reacted with an amine for
protein, peptide, enzyme modification (PEGylation).
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m-PEG-Lys-NHS ester
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BP-23761
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m-PEG-Lys-NHS ester, MW 20,000
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1g & 5g
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m-PEG-Lys-NHS ester, MW 20,000 is a PEG polymer NHS ester which can react with primary amine for
labeling proteins and antibodies.
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BP-23762
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m-PEG-Lys-NHS ester, MW 40,000
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1g & 5g
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m-PEG-Lys-NHS ester, MW 40,000 is an NHS ester polyPEG. It is reactive with amino group of protein or
other molecule for labeling application.
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