Current top sellers & new products of CellagenTech
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Current top sellers & new products of Cellagen Technology
Current top sellers
1st Product Name: J147
J147 was discovered based upon efficacy in multiple cell culture models of age-associated pathologies rather than
exclusively amyloid metabolism. It is an exceptionally potent, orally active and broadly neuroprotective compound has the
ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic
mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived
neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the
preservation of synaptic protein, the reduction of amyloid plaques, etc. These pleiotrophic effects of a single molecule
suggest that J147 has potential for the treatment of AD.
Details
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Chemical Formula: |
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C18H17F3IN2O2 |
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CAS No.: |
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1146963-51-0 |
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Molecular weight: |
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350.33 |
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Purity: |
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> 98% |
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Appearance: |
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Yellow solid |
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Chemical name: |
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(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide |
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Solubility: |
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Up to 50 mM in DMSO |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
Reference
1. Qi Chen, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One (2011),
6(12), e27865.
2nd Product Name: StemRegenin1 (SR1)
The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of
human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.
SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord
blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a
17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo
expansion of normal HSCs or leukemic stem/progenitor cells.
Details
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Chemical Formula: |
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C24H23N5OS |
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CAS No.: |
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1227633-49-9 |
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Molecular weight: |
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429.54 |
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Purity: |
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> 98% |
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Appearance: |
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White solid |
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Chemical name: |
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4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol |
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Solubility: |
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Up to 35 mM in DMSO |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
References
1. Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic
Stem Cells. Science 10 September 2010: 1345-1348.
2. Smith G.H. et al. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.
J Phar Exp Therap. 338 2011: 318-327
3rd Product Name: Y-27632
Y-27632 is widely used as a specific inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase
(ROCK) family. It has been found to prevent dissociation-induced apoptosis in human embryonic stem cells and enhance
the survival and cloning efficiency of dissociated hES cells without affecting their self-renewal properties or pluripotency.
Y-27632 can also enhance survival during the transplantation of ES cell-derived neural precursors.
Details
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Chemical Formula: |
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C32H31BrN2O2 |
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CAS No.: |
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146986-50-7 |
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Molecular weight: |
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329.27 |
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Purity: |
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> 98% |
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Appearance: |
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White solid |
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Chemical name: |
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(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide |
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Solubility: |
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Up to 100 mM in DMSO |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
References
1. Ishizaki, T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol
(2000) 57: 976-983.
2. Koyanagi et al. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem
cell-derived neural precursors. J. Neurosci Res (2008) 86: 270-280.
3. Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech (2007)
25: 681-686.
4th Product Name: TAK-875
TAK-875 is an orally-available, benzofuran-based, agonist of GPR40 for the potential treament of Type 2 diabetes mellitus,
with an human EC50 of 0.014 uM in a FLIPR assay. It has high selectivity over GPR41, GPR43, and GPR120, with EC50s all
greater than 10 uM. [1] Oral dosing (0.3-3 mg/kg) of TAK-875 in a glucose intolerance test in female Wistar rats reduced
blood glucose excursion. Insulin secretion was increased during an oral glucose tolerance test.
TAK-875 was shown to activate the Gqa-mediated signalling pathway in pancreatic b-cells. Prolonged agonist stimulation by TAK-875 revealed no evidence of b-cell dysfunction or toxicity, nor does it cause a induction of a marker of apoptosis in
pancreatic b-cells. [2]
Details
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Chemical Formula: |
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C29H32O7S.1/2H2O |
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CAS No.: |
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1000413-72-8 |
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Molecular weight: |
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533.63 |
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Purity: |
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> 98% |
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Appearance: |
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White |
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Chemical name: |
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[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphe-nyl-3-yl}meth-oxy)-2,3-
dihydro-1-benzofuran-3-yl]acetic acid hemi-hydrate |
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Solubility: |
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Up to 100 mM in DMSO |
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Synonyms: |
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TAK-875, TAK875 |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
References
1. Negoro et al., ACS Med. Chem. Lett. 2010, 1, 290-294.
2. Tsujihata et al., TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist,
enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2
New products
Product Name: T-705 (Favipiravir)
T-705 (Favipiravir) is an antiviral pyrazinecarboxamide-based, inhibitor of of the influenza virus with an EC90 of 1.3 to
7.7 uM (influenza A, H5N1). EC90 ranges for other influenza A subtypes are 0.19-1.3 uM, 0.063-1.9 uM, and 0.5-3.1 uM for
H1N1, H2N2, and H3N2, respectively. T-705 also exhibits activity against type B and C viruses, with EC90s of
0.25-0.57 uM and 0.19-0.36 uM, respectively. (1) Additionally, T-705 has broad activity against arenavirus, bunyavirus,
foot-and-mouth disease virus, and West Nile virus with EC50s ranging from 5 to 300 uM. (1)
Studies show that T-705 ribofuranosyl triphosphate is the active form of T-705 and acts like purines or purine nucleosides
in cells and does not inhibit DNA synthesis. (2)
Details
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Chemical Formula: |
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C5H4FN3O2 |
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CAS No.: |
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259793-96-9 |
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Molecular weight: |
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157.1 |
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Purity: |
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> 98% |
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Appearance: |
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Off white |
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Chemical name: |
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6-fluoro-3-hydroxy-2-pyrazinecarboxamide |
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Solubility: |
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Up to 100 mM in DMSO |
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Synonyms: |
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T-705, T705, Favipiravir |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
References
1. Furuta et al., T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.
2. Kiso et al., T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. 2010, 107(2),
Product Name: PQ401
PQ401 is a diarylurea-based inhibitor of IGF-1R, inhibiting autophosphorylation in MCF-7 cells and the IGF-1R isolated
kinase domain at IC50s of 12 uM and < 1 uM, respectively. In IGF-1R stimulated MCF-7 cells, PQ401 was more effective at
an IC50 of 6 uM. In MCF-7 cells IGF-1-mediated signaling is decreased by way of the Akt antiapoptotic pathway. Prolonged incubation with PQ401 induces a dose-dependent increase in caspase activation. (1)
Details
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Chemical Formula: |
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C18H16CIN3O2 |
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CAS No.: |
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196868-63-0 |
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Molecular weight: |
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341.79 |
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Purity: |
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> 98% |
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Appearance: |
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White |
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Chemical name: |
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N-(5-Chloro-2-methoxyphenyl)-N'-(2-methylquinolin-4-yl)urea |
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Solubility: |
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Up to 50 mM in DMSO |
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Synonyms: |
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PQ401, PQ-401 |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
Reference
1. Gable et al., Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast
cancer cell growth. Mol. Cancer Ther. 2006, 5, 1079-1086. Pubmed ID: 16648580
Ordering information
|
Catalog No. |
Product Name |
Size |
|
C5147-2 |
J-147 |
2mg, 10mg & 50mg |
|
C7710-1 |
StemRegenin1 (SR1) |
1mg, 5mg & 25mg |
|
C9127-2 |
Y-27632 |
2mg, 10mg & 50mg |
|
C8875-2 |
TAK-875 |
2mg, 10mg & 50mg |
|
C8705-5 |
T-705 (Favipiravir) |
5mg, 25mg & 100mg |
|
C7740-5 |
PQ401 |
5mg, 25mg & 100mg |
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