USP7 inhibitor-new product of Cellagen Technology
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P22077 / USP7 inhibitor-new products of Cellagen Technology
Product Name: P22077
P22077 is a potent and selective USP7 inhibitor. It specifically inhibits deubiquitylating enzyme (DUB) USP7 and the
closely related USP47 (at 5µM), but not the other majority of DUBs (at 15-45µM). USP7 has been found to be critical in
cancer progression due to its influence on the stability of the tumor suppressor p53. The inhibition of USP7 is predicted
to destabilize HDM2 and stabilize p53, and USP7 exerts both p53-dependent and p53-independent effects on
controlling cell proliferation and apoptosis.
Details
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Chemical Formula: |
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C12H7F2NO3S2 |
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CAS No.: |
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1247819-59-5 |
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Molecular weight: |
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315.32 |
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Purity: |
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> 98% |
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Appearance: |
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White |
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Chemical name: |
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1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone |
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Solubility: |
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Up to 50 mM in DMSO |
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Synonyms: |
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TMP195 |
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Storage: |
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Store solid powder at 4oC, or store DMSO solution at -20oC |
References:
1. Mikael Altun et al. Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes.
(2011) Chemistry & Biology 18, 1401–1412.
Ordering information
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Catalog No |
Product Name |
Size |
|
C7220 |
P22077 / USP7 inhibitor |
2mg, 10mg & 50mg |
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