각종 Acetylcholine Receptor Blocker Peptide Toxin(2)
본문
화학합성의 각종 Acetylcholine Receptor Blocker Peptide Toxin(2)
Acetylcholine receptor 연구에 유용한 유독 생물 유래의 합성 peptide toxin 입니다. 화학합성 peptide이기 때문에
endotoxin 오염의 걱정이 없습니다.
αC-conotoxin PrXA
αC-Conotoxin PrXA (AlphaC-PrXA) was originally isolated from the venom of the fish-hunting Conus parius. αC-
Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult
α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 =
3 nM). αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces
(with higher affinity however for the α/δ subunit interface). The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom.
αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.
Details
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AA sequence: |
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Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-Hyp-Phe-Ser-Cys13-Ala-Gly-Leu-Arg-Gly-Gly-Cys20-Val-
Leu-Pro-Hyp-Asn-Leu-Arg-Hyp-Lys-Phe-Lys-Glu-NH2 |
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|
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(Disulfide bonds between Cys13-Cys20) |
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Length (aa): |
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32 |
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Formula: |
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C160H249N43O44S2 |
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Molecular Weight: |
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3541.1 Da |
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Appearance: |
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White lyophilized solid |
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Solubility: |
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Water or saline buffer |
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CAS number: |
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NA |
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Source: |
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Synthetic |
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Purity rate |
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> 98 % |
References
1. Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors.
Philippine Science Letters
2. Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists.
Biochemistry. PubMed link
Ordering information
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Catalog No. |
Product Name |
Size |
|
13CON016 |
αC-Conotoxin PrXA |
0.1 mg & 0.5 mg |
* 다른 사이즈나 bulk 공급도 가능하오니 별도로 문의하여 주십시오.
▣ 관련 페이지 ; Smartox Biotechnology
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αC-Conotoxin PrXA /
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• 화학 합성의 각종 Potassium Channel Blocker Peptide Toxin
Agitoxin-2 / (Dap22)-ShK / ADWX-1
Iberiotoxin (IbTx) / Charybdotoxin / Leiurotoxin 1 / Tamapin / Guangxitoxin 1E / ShK (Stichodactyla toxin)/
Margatoxin / HsTx1 / Apamin / TERTIAPIN-Q / Maurotoxin / Kaliotoxin-1
• 화학 합성의 각종 Sodium Channel Blocker Peptide Toxin
Paurtx 3 /
Protoxin I (ProTx-1) / GsAF-I / GsAF-II / Jingzhaotoxin III / Biotinyl-Protoxin II (ProTx II) / Hainantoxin-IV /
Protoxin II (ProTx II) / Huwentoxin IV / Huwentoxin I / μ Conotoxin PIIIA (mu conotoxin PIIIA)
- 이전글화학합성의 Potassium Channel Blocker Peptide Toxin(4) 13.12.05
- 다음글화학합성의 Potassium Channel Blocker Peptide Toxin(3) 13.09.06
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