Products

 

 

Product Name: Kartogenin (KGN)
 

Kartogenin (KGN) is a potent and specific small molecule to promote chondrocyte differentiation and can be used in

cartilage cell engineering and cartilage repair after disease or injury.

Kartogenin was shown to promote robust chondrocyte differentiation from primary human mesenchymal stem cells/MSCs [EC50 = 100 nM]. In an in vitro model mimicking cytokine-induced damage during osteoarthritis (OA), 1-5 µM of

Kartogenin treatment inhibited nitric oxide (NO) and glycosaminoglycans (GAG) release. Direct Intra-articular

administration of Kartogenin promoted cartilage repair in collagenase and surgery induced OA models in mice, and

alleviated OA-induced joint pain. Mechanism of action studies showed that Kartogenin interacts with filamin A (FLNA) and results in the release of transcription factor CBFβ to the nucleus to regulate chondrogenic gene expression.

 

 

 

 

Reference:

1.Johnson K. et. al. A Stem Cell–Based Approach to Cartilage Repair. Science (2012) April 5. [Epub ahead of print].

 

 

 

 

 

 

C5278-2s (10 mM in DMSO)

C5278-2 (powder)

 

* Packing size: 2 mg 

 

 

Product Name: Leukadherin-1
 

 

Leukadherin-1 (LA1), a novel small molecule agonists of integrin CD11b/CD18, can increase the extent of CD11b/CD18-

dependent cell adhesion of transfected cells and of primary human and mouse neutrophils (EC50 =4µM in vitro), which

resulted in decreased chemotaxis and transendothelial migration. LA1 can also decrease leukocyte recruitment and

reduced arterial narrowing after injury in rats. Moreover, compared to a known integrin antagonist, LA1 preserved kidney function better in a mouse model of experimental nephritis. It inhibited leukocyte recruitment by increasing leukocyte

adhesion to the inflamed endothelium, which was reversed with a blocking antibody.

 

 

 

 

Reference:

 

1.Dony Maiguel, et al. Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease.

  Sci. Signal., Vol. 4, Issue 189, p. ra57
2.Faridi MH et al. Identification of novel agonists of the integrin CD11b/CD18. Bioorg Med Chem Lett. 2009; 19(24):

  6902-6.

 

 

    

 

 

 

 
C5385-2s (10 mM in DMSO)
C5385-2 (powder)

 

* Packing size: 2 mg 

 

 

Product Name: Pyrintegrin
 

 

Pyrintegrin is a selective, cell permeable, small molecule that was identified to help in promoting human embryonic stem

cell (hESC) survival by > 30-fold. The dramatic increase in cell survival has been attributed to the protection of the cell

surface protein e-cadherin from damage by Pyrintegrin.

 

 

 

 

Reference:

 

1.Xu, Y., Zhu, X. et al. 2010. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-

  renewal by small molecules. PNAS 107(18): 8129-8134.

 

 

    

 

 

 

C7974-1s (10 mM in DMSO)
C7974-1 (powder)

 

* Packing size: 2 mg